Waaqo Daddacha
Department Microbiology & Immunology University of Rochester School of Medicine and Dentistry
Investigate the role of HIV-1 central polypurine tract:
1) HIV-1 viral replication kinetics
2) HIV-1 sensitivity to drugs
Publication
Hanna-Mari Baldauf, Xiaoyu Pan, Elina Erikson, Sarah Schmidt, Waaqo Daddacha, Manja Burggraf, Kristina Schenkova, Ina Ambiel, Guido Wabnitz, Thomas Gramberg, Sylvia Panitz, Egbert Flory, Nathaniel R. Landau, Serkan Sertel, Frank Rutsch, Felix Lasitschka, Baek Kim, Renate König, Oliver T Fackler & Oliver T Keppler (In Press) SAMHD1 Restricts HIV-1 Infection in Resting CD4+ T Cells. Nature Medicine. 2012
Capella C, Beltejar MJ, Brown C, Fong V, Daddacha W, Kim B, Dewhurst S. Selective Modification of Adenovirus Replication can be Achieved Through Rational Mutagenesis of the Adenovirus Type 5 DNA Polymerase. J. Virol. 2012
Baek Kim, Laura A. Nguyen, Waaqo Daddacha, Joseph A. Hollenabaugh. Tight Interplay Among SAMHD1 Level, Cellular dNTP Levels and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-Derived Macrophages. J. Biol.Chem. 2012
David J. Mock, Joseph A. Hollenbaugh, Waaqo Daddacha, Michael G. Overstreet, Chris A. Lazarski, Deborah J. Fowell, and Baek Kim. Leishmania Induces Survival, Proliferation and Elevated Cellular dNTP levels in Human Monocytes Promoting Acceleration of HIV Co-infection.PLOS Pathogens. 2012
Hichem Lahouassa, Waaqo Daddacha, Henning Hofmann, Diana Ayinde, Eric C. Logue, Loïc Dragin, Nicolin Bloch, Claire Maudet, Matthieu Bertrand, Thomas Gramberg, Gianfranco Pancino, Stéphane Priet, Bruno Canard, Nadine Laguette, Monsef Benkirane, Catherine Transy, Nathaniel R. Landau, Baek Kim and Florence Margottin-Goguet. SAMHD1 restricts HIV-1 by reducing the intracellular pool of deoxynucleoside triphosphates. Nature Immunology. 2012.
Sarah K. Van Cor-Hosmer, Waaqo Daddacha, and Baek Kim. Mechanistic Interplay among the M184I HIV-1 Reverse Transcriptase Mutant, the central polypurine tract, cellular dNTP concentrations and drug sentivity.Virology. 2010